Clinical medicine profile
Aceclofenac / Thiocolchicoside
NSAID / analgesic–anti-inflammatory
- Route
- ORAL / TOPICAL / RECTAL / IM (agent-dependent)
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Active peptic ulcer / GI bleeding.
- Severe heart failure.
- NSAID-exacerbated respiratory disease (aspirin-sensitive asthma) for non-selective agents.
- Third trimester pregnancy (ductus arteriosus, oligohydramnios — class warning).
- Severe renal impairment for many agents.
- Hypersensitivity to NSAIDs.
Precautions
- Lowest effective dose, shortest duration.
- GI protection (PPI) if high risk.
- CV risk (MI/stroke) with many NSAIDs — caution in known CVD.
- Monitor renal function in elderly, diuretic/ACEI/ARB users (triple whammy).
- Avoid combining multiple NSAIDs.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
1 tab BD for 100mg/4mg tabs/caps or 1 tab OD for 200mg/8mg(16mg)
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Haemodynamically mediated AKI risk — high alert in volume depletion and renin-angiotensin blockade.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Rare idiosyncratic hepatitis; more concern with prolonged high doses/diclofenac in some datasets.
Use, effects & interactions
Indications
- Pain especially that of the neck and shoulder due to neuromuscular and skeletal spasm Clinical selection for Aceclofenac / Thiocolchicoside should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: NSAID / analgesic–anti-inflammatory.
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- Dyspepsia, nausea, fluid retention, raised BP.
- Serious: peptic ulcer/bleed, AKI, heart failure exacerbation, severe skin reactions, bronchospasm, hepatitis (rare).
Drug interactions
Open multi-drug checker ↗- Risk-stratify GI and CV before prescribing.
- Prefer topical NSAIDs for local MSK pain when adequate.
- Review after short courses.
- Educate on black stools/haematemesis red flags.
Mechanism & disposition
Aceclofenac is a NSAID while thiocolchicoside is a skeletal muscle relaxant.
Read complete mechanism
Aceclofenac is a NSAID while thiocolchicoside is a skeletal muscle relaxant. NSAIDs inhibit cyclo-oxygenase (COX-1 and/or COX-2), reducing prostaglandin and thromboxane synthesis. This yields analgesic, antipyretic and anti-inflammatory effects. COX-1 inhibition drives many GI and platelet adverse effects; COX-2 selective agents spare some GI risk but retain CV warnings.
30–60 minutes
4–12 hours (agent-dependent)
ORAL / TOPICAL / RECTAL / IM (agent-dependent)
of metabolites. Half-lives vary widely (ibuprofen short; naproxen longer; oxicams long).
Pregnancy, lactation & diet
[Aceclofenac] Avoid in third trimester. Earlier pregnancy: use only if needed; prefer paracetamol first-line. [Thiocolchicoside] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist.
[Aceclofenac] Short-course ibuprofen generally acceptable; avoid chronic high-dose/long half-life agents when possible. [Thiocolchicoside] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| Neorelax A 8mg Tablet | Meyer Organics Pvt.Ltd | Tablet 8mg | Unavailable |
| STEDNAC MR Tablets | STEDMAN PHARMACEUTICALS PVT. LTD. | Tablet | Unavailable |
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.