Clinical medicine profile
Diphtheria / Tetanus / Pertussis / Hepatitis B vaccine
Vaccine / immunological product
- Route
- IM / SC / ORAL / ID
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
A traceable source link is not attached to this profile. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Anaphylaxis to prior dose or component.
- Live vaccines contraindicated in significant immunosuppression and usually pregnancy.
- Defer for moderate–severe acute illness.
Precautions
- Temperature of 400C within 48 hours, not due to another identifiable cause, collapse or shock-like state within 48 hours, persistent crying lasting 3 hours, occurring within 48 hours, convulsions with or without fever, occurring within 3 days.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
0.5mL, three vaccine doses administered at intervals of at least 4 weeks.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
N/A generally.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
N/A generally.
Use, effects & interactions
Indications
- active immunisation against diphtheria, tetanus, pertussis and hepatitis B (HBV) in infants from 6 weeks onwards.
- Clinical selection for Diphtheria / Tetanus / Pertussis / Hepatitis B vaccine should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Vaccine / immunological product.
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- [Diphtheria] Local pain, low-grade fever, myalgia.
- Serious: anaphylaxis, vaccine-specific rare events (e.g. intussusception historically with some rotavirus products). [Pertussis] Adverse reactions vary by agent.
- Counsel on common predictable effects and serious warning symptoms (allergy, severe rash, jaundice, unusual bleeding, severe GI symptoms, neurological changes).
- Report suspected ADRs via national pharmacovigilance channels. [Hepatitis B vaccine] Local pain, low-grade fever, myalgia.
- Serious: anaphylaxis, vaccine-specific rare events (e.g. intussusception historically with some rotavirus products).
Drug interactions
Open multi-drug checker ↗- Fixed-dose/multi-ingredient product.
- Clinical details partially inherited from component monographs: Diphtheria / Tetanus / Pertussis / Hepatitis B vaccine.
- Confirm combination SmPC for exact dosing.
Mechanism & disposition
Combination product.
Read complete mechanism
Combination product. Component mechanism (Diphtheria / Tetanus / Pertussis / Hepatitis B vaccine): MOA-ID_37 Vaccines present antigen to the adaptive immune system to generate protective antibodies and memory cells without causing full disease (or using attenuated/inactivated/subunit/mRNA platforms). Immunoglobulins provide passive temporary immunity.
Immune response days–weeks
Months–lifelong (schedule-dependent)
IM / SC / ORAL / ID
are product-specific. Consider food effects, protein binding, hepatic CYP/UGT
when adjusting for organ impairment, age and drug interactions. Verify parameters in the current SmPC. [Hepatitis B vaccine] Not classical PK; immunogenicity and cold-chain integrity determine effectiveness.
Pregnancy, lactation & diet
[Diphtheria] Inactivated vaccines (e.g. influenza, Tdap) often recommended; live vaccines generally avoided. [Pertussis] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [Hepatitis B vaccine] Inactivated vaccines (e.g. influenza, Tdap) often recommended; live vaccines generally avoided.
[Diphtheria] Most vaccines compatible; live vaccines usually fine for breastfeeding mother. [Pertussis] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data. [Hepatitis B vaccine] Most vaccines compatible; live vaccines usually fine for breastfeeding mother.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.