Clinical medicine profile
Diosmin/Hesperidin(semi-synthetic)
Therapeutic agent (verify pharmacological class)
- Route
- See product SmPC
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- CONTRAINDICATIONS: Do not use if you have a known allergy to any of the ingredients in Bruselix™ Bruising Tablets , including Arnica Montana or pineapple (Bromelain).
- Avoid use if you have an allergy to citrus or bioflavonoid components.
Precautions
- WARNINGS AND PRECAUTIONS Arnica: May cause allergic reactions in sensitive individuals, especially if there is a history of ragweed allergies.
- Bromelain: May increase the risk of bleeding in individuals taking anticoagulants or antiplatelet medications.
- Discontinue use two weeks before surgery.
- Zinc and Vitamin C: Use cautiously in individuals with kidney disease or those prone to kidney stones.
- If you experience an allergic reaction or prolonged bleeding, discontinue use and seek medical attention immediately.
- For use on the order of a licensed healthcare practitioner.
- Call your doctor about side effects.
- To report side effects, call PureTek Corporation at 1-877-921-7873.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
DOSAGE AND ADMINISTRATION: Take one (1) Bruselix™ Bruising Tablets daily, or as directed by a licensed healthcare practitioner. Do not exceed recommended dose.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Review renal impairment dosing; many agents need CrCl/eGFR adjustment.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Review hepatic impairment dosing; monitor LFTs if agent is hepatically cleared or hepatotoxic.
Use, effects & interactions
Indications
- INDICATIONS AND USAGE: Bruselix™ Bruising Tablets are formulated to provide nutritional support during the body’s natural recovery process.
- They may be helpful for individuals experiencing bruising due to minor injuries, surgical procedures, or sensitive skin.
- The formula contains antioxidants, enzymes, and natural extracts that are traditionally used to support overall skin health and recovery.
Adverse effects
- Adverse Reactions: Adverse reactions associated with the use of Bruising Tablets may include mild gastrointestinal discomfort, nausea, or allergic reactions such as skin rash.
- In rare cases, more serious reactions, such as prolonged bleeding or hypersensitivity reactions (e.g., difficulty breathing, swelling), may occur.
- If you experience any serious adverse effects, discontinue use and seek medical attention immediately.
Drug interactions
Open multi-drug checker ↗- Fixed-dose/multi-ingredient product.
- Clinical details partially inherited from component monographs: Diosmin / Hesperidin.
- Confirm combination SmPC for exact dosing.
Mechanism & disposition
Combination product.
Read complete mechanism
Combination product. Component mechanism (Diosmin / Hesperidin): Vascular protector and venotonic that acts on the return vascular system reducing venous distensibility and venous stasis. It also normalizes capillary permeability besides reinforcing capillary resistance.
Product-specific
Product-specific
See product SmPC
are product-specific. Consider food effects, protein binding, hepatic CYP/UGT
when adjusting for organ impairment, age and drug interactions. Verify parameters in the current SmPC.
Pregnancy, lactation & diet
Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist.
Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| Diosmin/Hesperidin [semi-synthetic] | Afya Index / Retail Reference | mg/ 50mg 30's | KES 454.25afya_index_book |
| Diosmin [semi-synthetic] | Afya Index / Retail Reference | mg/ 50mg 30's | KES 504.00afya_index_book |
| Ethamsylate/Tranexamic Acid | Afya Index / Retail Reference | mg/ 250mg 1x10's | KES 883.00afya_index_book |
| Sylent-TX | Afya Index / Retail Reference | tabs 500mg 30's | KES 869.00afya_index_book |
| Tramed | Afya Index / Retail Reference | mg / 250mg 10's | KES 400.00afya_index_book |
| Transamin | Afya Index / Retail Reference | 500mg 5 x Kenya: inj, 100mg/ml [10's x 5mL | KES 1,000.00afya_index_book |
| TX-MF | Afya Index / Retail Reference | mg/ 250mg 30's | KES 1,665.00afya_index_book |
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.