AfyaIndex
Kenyan Reference & Directory
Free lookups: 0/3 Unlock Pro
Clinical reference Find a medicine
Ctrl K
Drug categories Interaction checker
0 of 3 free lookups remaining Upgrade
New search Medicine profile Aceclofenac / Paracetamol
Check interactions

Clinical medicine profile

Aceclofenac / Paracetamol

NSAID + paracetamol combination

POM
Evidence state Source-linked Review date not recorded
Route
ORAL / RECTAL / IV
Schedule
POM
ATC
Not assigned
PPB status
registered
Patient advice Check interactions
01 Risk first

Safety essentials

The information most likely to change a prescribing or dispensing decision.

Contraindications

  • [Aceclofenac] Active peptic ulcer / GI bleeding.
  • Severe heart failure.
  • NSAID-exacerbated respiratory disease (aspirin-sensitive asthma) for non-selective agents.
  • Third trimester pregnancy (ductus arteriosus, oligohydramnios — class warning).
  • Severe renal impairment for many agents.
  • Hypersensitivity to NSAIDs. [Paracetamol] Severe active hepatic disease / acute liver failure.
  • Hypersensitivity.
  • Chronic heavy alcohol use — use reduced maximum daily dose or avoid.

Precautions

  • [From component Paracetamol] Risk of severe hepatotoxicity in overdose.
  • Chronic high-dose use, malnutrition, enzyme-inducing drugs, and alcohol increase risk.
  • Check total daily intake from all sources.
02 Point of care

Dosing matrix

Population and organ-function guidance, shown together for faster comparison.

Adult

Dosing is indication-, age-, weight- and organ-function-specific for this INN. Do not use class averages for high-risk patients. Confirm the exact regimen in the current SmPC and Kenya Standard Treatment Guidelines. Typical professional workflow: (1) confirm indication, (2) check renal/hepatic function, (3) screen interactions/allergies, (4) select dose/route/duration, (5) define monitoring.

Paediatric

Usually not children.

Renal

Avoid significant RI.

  • CrCl 0–120: See renal_dose_adjustment; confirm product SmPC.
Hepatic

Avoid active liver disease.

03 Clinical use

Use, effects & interactions

Indications

  • Short-term pain/inflammation when combo product used.
  • Clinical selection for Aceclofenac / Paracetamol should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
  • Class context: NSAID + paracetamol combination.
  • Confirm site-specific dose, duration and monitoring before prescribing.

Adverse effects

  • [Aceclofenac] Dyspepsia, nausea, fluid retention, raised BP.
  • Serious: peptic ulcer/bleed, AKI, heart failure exacerbation, severe skin reactions, bronchospasm, hepatitis (rare). [Paracetamol] Rare at therapeutic doses.
  • Serious: acute liver failure in overdose, rare severe skin reactions (SJS/TEN/AGEP).

Drug interactions

Open multi-drug checker ↗
  • Alphabetical A-series MyDrugIndex generic monograph.
  • Fixed-dose/multi-ingredient product.
  • Clinical details partially inherited from component monographs: Paracetamol.
  • Confirm combination SmPC for exact dosing.
04 Pharmacology

Mechanism & disposition

Inhibitors of cyclo-oxygenase [COX-1 and COX-2] enzyme that catalyzes the conversion of arachidonic acid to PGH2.

Inhibit COX↓ ProstaglandinsAnalgesia / anti-inflammatory
Read complete mechanism

Inhibitors of cyclo-oxygenase [COX-1 and COX-2] enzyme that catalyzes the conversion of arachidonic acid to PGH2. Paracetamol inhibits central prostaglandin synthesis via effects on cyclo-oxygenase pathways (including COX-2 preferential central effects) and may engage serotonergic descending pathways. Antipyretic effect via hypothalamic heat-regulating centre. Minimal peripheral anti-inflammatory action.

Onset

30–60 minutes oral

Duration

4–6 hours

Route

ORAL / RECTAL / IV

Metabolism

(glucuronidation/sulfation); toxic NAPQI pathway via CYP2E1 when pathways saturated or glutathione depleted.

Half-life

~2–3 h; prolonged in liver disease/overdose.

05 Special populations

Pregnancy, lactation & diet

Pregnancy

[Aceclofenac] Avoid in third trimester. Earlier pregnancy: use only if needed; prefer paracetamol first-line. [Paracetamol] Analgesic/antipyretic of choice in pregnancy when needed; use lowest effective dose/shortest duration.

Lactation

Compatible with breastfeeding at standard doses.

06 Kenya market

Brands & loaded prices

FromKES 160
MedianKES 172
Listings11
BrandManufacturerPackObserved price
ACEPAR CAPS 10`S Not recorded — KES 186.90Daima Chemist price-list reference ↗ Source date not recorded · verify current price
ACEPAR MR 10*S Not recorded — UnavailableDaima Chemist price-list reference
ACEPAR SP TABS 10*S Not recorded — UnavailableDaima Chemist price-list reference
ACP-MR TABS 10*S Not recorded — KES 160.17Daima Chemist price-list reference ↗ Source date not recorded · verify current price
ACP CAPS 30*S Not recorded — UnavailableDaima Chemist price-list reference
ACP SP TABS 10*S Not recorded — KES 203.17Daima Chemist price-list reference ↗ Source date not recorded · verify current price
ACP TH8 TABS 10`S Not recorded — UnavailableDaima Chemist price-list reference
Ceclonec-p Afya Index product / manufacturer unverified mg/ 500mg 10's Unavailable
LYSODOL P DAIMA BIASHARA / Wholesale Import — KES 172.00daima_biashara_price_list
Zerodol-p IPCA mg / 500mg 30's Unavailable
ZYRTAL PLUS 100/1000 PHARMAKEN LTD Tablet Unavailable
07 Provenance

Sources & review state

Primary sourceLocal active-ingredient clinical extract; Batch A alphabetical research (INN; confirm vs SmPC/local guidelines); RxNorm (NLM RxNav); PubChem
Last reviewedNot recorded
EvidenceSource-linked
Open source document ↗

Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.