Clinical medicine profile
Vitamin D related compound
Vitamin / mineral / nutritional supplement
- Route
- ORAL / IM / IV (selected)
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
A traceable source link is not attached to this profile. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
- Iron: avoid in iron overload.
- Potassium: severe hyperkalaemia / untreated Addison's.
Precautions
- Treat confirmed deficiency with monitored repletion.
- Avoid megadoses without indication.
- Iron: keep away from children (overdose lethal).
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
For Vit. D deficiency: 400 I.U of Vit. D. For Vit. D deficiency caused by intestinal malabsorption or chronic liver disease; 40,000 I.U daily of calciferol. For hypocalcemia of hypopar- athyroidism: Up to 100,000 I.U daily.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Fat-soluble vitamins and potassium need care in advanced CKD.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Vitamin A toxicity hepatic; niacin hepatotoxicity at high dose.
Use, effects & interactions
Indications
- Simple Vitamin D deficiency due to nutritional
- hypophosphataemia.
- Clinical selection for Vitamin D related compound should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Vitamin / mineral / nutritional supplement.
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- Bone pain
- constipation
- diarrhea
- drowsiness
- dry mouth
- headache
- metallic taste
- muscle pain
- vomiting
- increase in frequency of urination [especially at night] or in the amount of urine
- loss of appetite
- unusual tiredness or weakness
- cloudy urine
- lethargy
Drug interactions
Open multi-drug checker ↗- Sources of Vitamin D: Milk
- animal fat
- oils and eggs.
- Exposure of the skin to UV rays in sunlight results in formation of cholecalciferol [Vitamin D3].
- Deficiency causes rickets in children and osteomalacia in adults.
Mechanism & disposition
Vitamin D3[cholecalciferol] and Vitamin D2[ergocalciferol] - which are natural forms of Vitamin D]- are transported to the liver where they are converted to calcifediol [25- hydroxycholecalciferol].
Read complete mechanism
Vitamin D3[cholecalciferol] and Vitamin D2[ergocalciferol] - which are natural forms of Vitamin D]- are transported to the liver where they are converted to calcifediol [25- hydroxycholecalciferol]. This is then transported to the kidneys and converted to calcitriol [1, 25- dihydroxycholecalciferol], which is thought to be the most active form of Vitamin D. It is required for absorption of calcium and phosphorus from the intestine. It also controls the amount of calcium in the bones [with parahormone]. These active forms of vitamin D should be prescribed in severe renal impairment when there is require- ment of Vitamin. D therapy.
Days–weeks for repletion
Depends on stores and ongoing intake
ORAL / IM / IV (selected)
depends on GI integrity, food matrix and binders (e.g. calcium/iron interactions). Fat-soluble vitamins (A,D,E,K) accumulate; water-soluble generally renally cleared.
Pregnancy, lactation & diet
Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A.
Maternal repletion often appropriate; avoid megadoses.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| OZICAL TABLETS 30*S | Not recorded | — | KES 879.55Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
| VITA CDZ 20*S | Not recorded | TABS | KES 537.50Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
| VITA UVD3 | Not recorded | CAPS | UnavailableDaima Chemist price-list reference |
| XTRACAL HD TABS 100`S | Not recorded | — | KES 1,166.81Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.