Clinical medicine profile
Sulphur/Salicylic AcidSulphur/ Aluminium Chlorhydroxide /Methyl Prednisolone / Neomycin Sulphate
alpha-Adrenergic Agonist [EPC], beta-Adrenergic Agonist [EPC], Catecholamine [EPC]
- Route
- ORAL / IV / IM / INHALED / TOPICAL / NASAL / OPHTHALMIC
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Systemic fungal infections (untreated) for systemic steroids.
- Live vaccines with significant immunosuppression.
- Hypersensitivity.
- Topical: untreated skin infection at site (relative).
Precautions
- WARNINGS: If pregnant or breast-feeding, ask a health professional before use.
- Keep out of reach of children.
- In case of overdose, get medical help or contact a Poison Control Center right away.
- Do not use if tamper evident seal is broken or missing.
- Store in a cool, dry place.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
DIRECTIONS: Adults and children 5 to 10 drops orally, 3 times daily or as otherwise directed by a health care professional. If symptoms persist for more than 7 days, consult your health care professional. Consult a physician for use in children under 12 years of age.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Fluid retention/hypertension — care in renal disease.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Prednisone needs hepatic activation to prednisolone.
Use, effects & interactions
Indications
- INDICATIONS: May temporarily relieve sinus congestion, runny nose, and sneezing.** **Claims based on traditional homeopathic practice, not accepted medical evidence.
- Not FDA evaluated.
- Clinical selection for Sulphur/Salicylic AcidSulphur/ Aluminium Chlorhydroxide /Methyl Prednisolone / Neomycin Sulphate should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: alpha-Adrenergic Agonist [EPC], beta-Adrenergic Agonist [EPC], Catecholamine [EPC].
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- [From component Salicylic Acid /Flumetasone Pivalate] Local irritation e.g burning sensation and itching, erythema rare, dryness of the skin, aggravation of concurrent untreated infections, thinning of the skin (this may be reversible), loss of skin elasticity, folliculitis, change in skin pigmentation, telangiectasia, purpura and steroid acne, increased growth of hair, severe pituitary-adrenal axis suppression and hypercotism, cushoid state, growth retardation, benign intra-cranial hypertension.
Drug interactions
Open multi-drug checker ↗- Fixed-dose/multi-ingredient product.
- Clinical details partially inherited from component monographs: Salicylic Acid /Flumetasone Pivalate, Methyl prednisolone.
- Confirm combination SmPC for exact dosing.
Mechanism & disposition
Combination product.
Read complete mechanism
Combination product. Component mechanism (Methyl prednisolone): It diffuses across cell membranes and forms a complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, binds to DNA, and stimulate transcription of messenger RNA [mRNA]. Messenger RNA leads to protein synthesis of various enzymes that are responsible for the effects of systemic corticosteroids. Betamethasone may suppress transcription of mRNA in some cells like lymphocytes.
Hours–days
Agent and route dependent
ORAL / IV / IM / INHALED / TOPICAL / NASAL / OPHTHALMIC
Pregnancy, lactation & diet
[Sulphur] Used when maternal benefit clear; prefer agents with better obstetric data (e.g. prednisolone). Document risk–benefit. [Salicylic AcidSulphur] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [Methyl Prednisolone] Used when maternal benefit clear; prefer agents with better obstetric data (e.g. prednisolone). Document risk–benefit.
[Sulphur] Low-dose systemic often compatible; time feeds if high dose — agent-specific. [Salicylic AcidSulphur] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data. [Methyl Prednisolone] Low-dose systemic often compatible; time feeds if high dose — agent-specific.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.