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New search Medicine profile Methylcobalamin 500mcg, Alpha Lipoic Acid 100mcg
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Clinical medicine profile

Methylcobalamin 500mcg, Alpha Lipoic Acid 100mcg

Vitamin / mineral / nutritional supplement

POM
Evidence state Source-linked Review date not recorded
Route
ORAL / IM / IV (selected)
Schedule
POM
ATC
Not assigned
PPB status
registered
Patient advice Check interactions
01 Risk first

Safety essentials

The information most likely to change a prescribing or dispensing decision.

Contraindications

  • Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
  • Iron: avoid in iron overload.
  • Potassium: severe hyperkalaemia / untreated Addison's.

Precautions

  • Treat confirmed deficiency with monitored repletion.
  • Avoid megadoses without indication.
  • Iron: keep away from children (overdose lethal).
02 Point of care

Dosing matrix

Population and organ-function guidance, shown together for faster comparison.

Adult

Adult: Megaloblastic anaemia caused by vit B12 deficiency: 500 mcg per day 3 times a week for about 2 month. Maintenance: 500 mcg 1-3 monthly. For peripheral neuropathies 1,500 mcg per day in 3 divided doses.

Paediatric

See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.

Renal

Fat-soluble vitamins and potassium need care in advanced CKD.

  • CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Hepatic

Vitamin A toxicity hepatic; niacin hepatotoxicity at high dose.

03 Clinical use

Use, effects & interactions

Indications

  • Therapeutic use is agent- and indication-specific within the class (Vitamin / mineral / nutritional supplement).
  • Use according to culture results, national guidelines (Kenya STG/EML where applicable) and the current product SmPC.
  • Vitamin B12 deficiency

Adverse effects

  • GI upset (iron, high-dose vitamin C).
  • Hypercalcaemia (vitamin D excess).
  • Neuropathy with B6 megadoses.
  • Flushing (niacin).

Drug interactions

Open multi-drug checker ↗
  • Prefer food-first then targeted replacement.
  • Document laboratory indication for high-dose therapy.
  • Public health: vitamin A, iron, folate programmes per MoH guidance.
04 Pharmacology

Mechanism & disposition

Vitamins and minerals act as cofactors, antioxidants, structural elements or hormone precursors (e.

Vitamins and minerals act as cofactors, an…Pharmacological high-dose effects differ f…
Read complete mechanism

Vitamins and minerals act as cofactors, antioxidants, structural elements or hormone precursors (e.g. vitamin D endocrine axis). Pharmacological high-dose effects differ from nutritional repletion.

Onset

Days–weeks for repletion

Duration

Depends on stores and ongoing intake

Route

ORAL / IM / IV (selected)

Absorption

depends on GI integrity, food matrix and binders (e.g. calcium/iron interactions). Fat-soluble vitamins (A,D,E,K) accumulate; water-soluble generally renally cleared.

05 Special populations

Pregnancy, lactation & diet

Pregnancy

Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A.

Lactation

Maternal repletion often appropriate; avoid megadoses.

06 Kenya market

Brands & loaded prices

From—
Median—
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BrandManufacturerPackObserved price
No reviewed brand listings are linked yet.
07 Provenance

Sources & review state

Primary sourceLocal active-ingredient clinical extract; RxNorm (NLM RxNav); PubChem; Professional class pharmacology (Vitamin / mineral / nutritional supplement)
Last reviewedNot recorded
EvidenceSource-linked
Open source document ↗

Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.